en Nursing Original Article <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Times New Roman;"><b>Background:</b> Family caregivers of cancer patients encounter numerous challenges while providing care, and self-efficacy is a key factor in alleviating these negative effects. This study aimed to investigate the psychometric properties of the Persian version of the Caregiver Self-Efficacy Scale (CSES) among caregivers of cancer patients.<br> <b>Methods:</b> This methodological study employed a cross-sectional design involving 382 family caregivers of cancer patients in a teaching hospital in Iran, in 2024. The CSES was translated into Persian using the forward-backward procedure. The initial translation was assessed for face and content validity through both quantitative and qualitative methods. Construct validity was evaluated using exploratory and confirmatory factor analysis. Discriminant validity was examined using the Heterotrait&ndash;Monotrait (HTMT) ratio. Reliability was assessed by evaluating internal consistency using Cronbach&#39;s alpha and Mcdonald&#39;s omega, and stability was measured using intraclass correlation coefficients (ICCs).<br> <b>Results:</b> In this study, 53.7% of the participants were male, and the caregivers&#39; mean age was 42.52 &plusmn; 11.83 years. Scale-level content validity index was reported 0.97 by expert panel during content validity stage. During the exploratory factor analysis, one item was excluded, leaving seven items were categorized into two factors: caregiver self-management and patient challenges. These factors collectively accounted for 43.9% of the variance in self-efficacy. Confirmatory factor analysis confirmed the adequacy of the model derived from the exploratory factor analysis (RMSEA = 0.05, GFI = 0.947, and CFI = 0.906). The factors demonstrated discriminant validity.&nbsp; Cronbach&#39;s alpha values for the patient challenges and caregiver self-management factors were 0.802 and 0.798, respectively. In addition, the ICC for these two factors was reported to be 0.830 and 0.802, respectively.<br> <b>Conclusion</b>: The Persian adaptation of the CSES demonstrates satisfactory validity and reliability for assessing the self-efficacy of family caregivers of cancer patients in Iran.</span></span><br> &nbsp;</div> Self Efficacy, Caregivers, Validity, Reliability, Psychometrics 13 18 http://nmj.goums.ac.ir/browse.php?a_code=A-10-1997-1&slc_lang=en&sid=1 Seyedmohammad Mirhosseini smohammadmh@gmail.com 100319475328460015213 100319475328460015213 No Department of Nursing, School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, Iran ; Student Research Committee, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran Ali Abbasi abbasi_msn@yahoo.com 100319475328460015214 100319475328460015214 No Department of Nursing, School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, Iran Anahita Divani anahitadivani114@gmail.com 100319475328460015215 100319475328460015215 No Department of Medical Surgical Nursing, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran Fateme Askarinezhad shaparaka3karinezhad@gmail.com 100319475328460015216 100319475328460015216 No Student Research Committee, School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, Iran Soheila Hasanpournamaghi sohee7926@gmail.com 100319475328460015217 100319475328460015217 No Student Research Committee, School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, Iran Samuel Grimwood samuel.grimwood@googlemail.com 100319475328460015218 100319475328460015218 No Human Sciences Research Centre, The University of Derby, Derby, United Kingdom Ali Montazeri amontazeri76@gmail.com 100319475328460015219 100319475328460015219 No Imam Hossein Hospital, Shahroud University of Medical Sciences, Shahroud, Iran Hossein Ebrahimi ebrahimi@shmu.ac.ir 100319475328460015220 100319475328460015220 Yes Center for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran